You should plan what weapons your characters will use.
First of all, so that you know what Attributes, Skills and Perks you want to develop, and secondly, because of the need to use a variety of ammunition.
The amount of available ammunition in the game is limited. The more powerful the weapon, the more difficult ammunition to get. So, when choosing the weapons you use, out of their range and the amount of damage they deal, keep in mind the amount of ammunition available.
It is worth considering weapons that do not require ammunition and the even distribution of weapon types between members of your team.
Assault Rifle
Assault rifles are the wasteland all-rounders. Mobile, quick to fire, with decent range, and decent damage. They also penetrate all but the heaviest of armor. Get one for everyone on your Christmas list.
Skill: Automatic Weapons
Recommended Attributes: Coordination, Awareness & Speed.
Damage: Average
Range: Average
Accuracy: Average
Armor Penetration: Average
Submachine Gun
If you've got a clear shot (like you're shooting some punk in the back) an SMG is devastating. They're not so great against enemies in cover or heavy armor, so you've gotta be mobile and pick your targets. But when you do - damn!
Skill: Automatic Weapons
Recommended Attributes: Coordination, Awareness & Speed.
Damage: High
Range: Low
Accuracy: High
Armor Penetration: Low
Semi Auto Pistol, Revolver
Pistols are accurate and quick, and deal solid damage to unarmored enemies, but have a hard time penetrating armor. On the plus side, if you want to quickly build your Strike Meter, they're a terrific choice!
Skill: Small Arms
Recommended Attributes: Coordination, Luck & Awareness.
Damage: Average
Range: Average
Accuracy: High
Armor Penetration: Low
Pump Shotgun
You won't do a lot of damage to single enemies with a shotty, but if you wanna hurt two or three at once, they're the way to go. Everyone in front of you will catch some lead. They're also great for blowing away enemy cover.
Skill: Small Arms
Recommended Attributes: Coordination, Luck & Awareness.
Damage: High
Range: Low
Accuracy: Average
Armor Penetration: Low
Sniper Rifle
Sniper rifles are too slow and too heavy to fire on the move, but they have fantastic range, high armor penetration, and do a ton of damage. So find a nice, quiet spot, sit yourself down, and get to sniping.
Skill: Sniper Rifles
Recommended Attributes: Intelligence, Awareness & Luck.
Damage: High
Range: High
Accuracy: High
Armor Penetration: High
Bladed Weapon
Your best friend in the wastes is a finely honed blade. Blades and are perfect for fighters who like to get up close and personal. They strike often, and deal high damage to enemies with light armor.
Skill: Melee Combat
Recommended Attributes: Strength, Coordination & Speed.
Damage: High
Range: Melee
Accuracy: High
Armor Penetration: Low
Blunt Weapon
It doesn't get more basic than hitting people with a stick - or more satisfying! Blunt weapons deal high damage to enemies in heavy armor, and with a little training, you can stun with them too.
Skill: Melee Combat
Recommended Attributes: Strength, Coordination & Speed.
Damage: High
Range: Melee
Accuracy: Average
Armor Penetration: High
Brawling Weapon
Sometimes you just wanna haul off and sock somebody. Brawlers start out weak but have huge potential at higher levels. They also gain critical hit bonuses for each consecutive strike, so make with the jabby-jabby.
Skill: Brawling
Recommended Attributes: Coordination, Intelligence & Charisma.
Damage: Range: Melee Accuracy: Average Armor Penetration: High
Heavy Weapons: Flamethrower, Heavy Machine Gun, Rocket Launcher
Heavy machine guns deal tons of damage and punch through armor with ease. Shooting them while moving, however, is almost impossible. They're far too heavy and inaccurate. But with training they're great for laying down covering fire.
Skill: Big Guns, Explosives
Recommended Attributes: Awarenesss, Coordination & Strength.
Damage: High
Range: Average
Accuracy: Low
Armor Penetration: High