Little China Unique Weapons
Dying Night
Power Pistol
Location: Little China, Side Job Shoot to Thrill, reward in shooting contest.
Base Weapon: m-10AF Lexington - +50% Headshot Damage, reduced reload time.
Scalpel
Katana
Location: Little China, Side Job Big in Japan, reward in Arasaka Waterfront on end of Job.
Base Weapon: Katana - While Sandevistan cyberware is active Crit Chance +50% and Bleeding.
Prejudice
Power Assault Rifle
Location: Little China, Afterlife, beginning of Main Job To Whom the Bell Tolls, behind the bar..
Base Weapon: HJSH-18 Masamune - Piercing projectiles.
Kabuki Unique Weapons
Sir John Phallustiff
One-Handed Club
Location: Kabuki, Stout will give it after Venus in Furs, if you buy Flathead without cracking the chip or warning Royce in Main job The Pickup.
Base Weapon: Electric Baton Gamma
Lizzie
Tech Pistol
Location: Kabuki, Main Job The Space in Between, Lizzie basement.
Base Weapon: Omaha - Extra round per shot.
Mox
Power Shotgun
Location: Kabuki, After an affair with Judy or in her apartment if she decide to leave.
Base Weapon: Carnage - Low reload speed.
Apparition
Tech Pistol
Location: Kabuki, Side Job War Pigs, loot from Frank's body
Base Weapon: JKE-X2 Kenshin - On low health will increases Critical Chance, Fire Rate and Reload Speed and damage when your health is very low. Charged shots deal double damage.
Second Opinion
This weapon is not present in the game.
Power Pistol
Location: Kabuki, Japan Town
Base Weapon: Nue
Northside Unique Weapons
Chaos
Tech Pistol
Location: Northside, Main Job The Pickup, looting Royce.
Base Weapon: JKE-X2 Kenshin - Random Crit Chance and Damage Type
Doom Doom
Power Revolver
Location: Northside, Side Job Second Conflict, Totentantz Club looting Dum Dum, if Dum Dum is still alive after The Pickup.
Base Weapon: DR5 Nova - Fires four rounds per shot.
Buzzsaw
Power Submachine Gun (have to be crafted)
Location: Northside (West), boss in Suspected Organized Crime Activity
Base Weapon: DS1 Pulsar - Fires piercing projectiles.
Psalm 11:6
Power Assault Rifle (have to be crafted)
Location: Northside, boss in Suspected Organized Crime Activity
Base Weapon: D5 Copperhead, thermal damage with a chance to burn
Fenrir
Power Submachine Gun
Location: Northside, Side Job Losing My Religion, on table near monk you try to rescue.
Base Weapon: M221 Saratoga - Cause burning.
Malorian Arms 3516
Power Pistol
Location: Northside, Side Job Chippin' In, Grayson.
Base Weapon: Unique Johnny Silverhand's pistol, four mods slots.
Ba Xing Chong
Smart Shotgun (have to be crafted)
Location: Northside, Adam Smasher's vault on Ebunike, but it will be available only after starting Main Job Nocturne Op55N1
Base Weapon: L-69 Zhuo - Fires explosive rounds.
Arasaka Waterfront Unique Weapons
Kongou
Power Pistol
Location: Arasaka Waterfront, Main Job The Heist, in penthouse, nightstand near Yorinobu's bed.
Base Weapon: Liberty - ricochet bullets without cyberware.
Satori
Katana
Location: Arasaka Waterfront, Main Job The Heist, up the stairs in vehicle on AV landing pad.
Base Weapon: Katana - increased Crit Damage.
Japantown Unique Weapons
Sovereign
Power Double-Barrel Shotgun (have to be crafted)
Location: Japantown, boss in Suspected Organized Crime Activity.
Base Weapon: DB-4 Igla - two rounds per shoot, reduced reload time.
Cocktail Stick
Katana
Location: Japantown, Main Job Automatic Love, Clouds Club upstairs, makeup room
Base Weapon: Katana - High base damage.
Cottonmouth
Two-Handed Club
Location: Japantown, Main Job The Space In Between, Fingers bedroom.
Base Weapon: Electric Baton Gamma
Jinchu-maru
Katana
Location: Japantown, Main Job Play it Safe, dropped by Oda
Base Weapon: Katana - While Kerenzikov cyberware is active Crit Chance 100%.
Tsumetogi
Katana
Location: Japantown, Side Job Pisces, in room where you meet Maiko.
Base Weapon: Katana - deals electrical damage and Shock, also increases electrical resistance.
Genjiroh
Smart Pistol
Location: Japantown, Main Job Play it Safe, behind a closed door on way to second sniper.
Base Weapon: HJKE-11 Yukimura - Fires four rounds per shot, larger magazine size, up to six targers.
Ozob's Nose
Grenade
Location: Japantown, Side Job Send in the Clowns Reward.
Base Weapon: Frag Grenade - high damage.
North Oak Unique Weapons
The Headsman
Power Shotgun (have to be crafted)
Location: North Oak, boss in Suspected Organized Crime Activity.
Base Weapon: M2038 Tactician - reduced reload time and Bleeding
Gold Plated Baseball Bat
Two-Handed Club
Location: North Oak, Side Job Second Conflict, pool in Denny's villa.
Base Weapon: Baseball Bat - Chance to bleed and stun.
West Wind Estate Unique Weapons
Moron Labe
Power Assault Rifle (have to be crafted)
Location: West Wind Estate, boss in Suspected Organized Crime Activity
Base Weapon: M251s Ajax - increased Rate of Fire.
Rancho Coronado Unique Weapons
Breakthrough
Tech Sniper Rifle (have to be crafted)
Location: Rancho Coronado (South), boss in Suspected Organized Crime Activity
Base Weapon: Nekomata - Ricochet piercing projectiles.
Divided We Stand
Smart Assault Rifle
Location: Rancho Coronado, Side Job Stadium Love, shooting contest reward or looted from contest participants.
Base Weapon: D5 Sidewinder - Can target up to five enemies at once.
Arroyo Unique Weapons
Comrade's Hammer
Tech Revolver (have to be crafted)
Location: Arroyo, boss in Suspected Organized Crime Activity
Base Weapon: RT-46 Burya - High damage, but low clip size and long reload times.
O'Five
Power Sniper Rifle
Location: Arroyo, Beat on the Brat: Arroyo, defeating and loot Buck.
Base Weapon: SPT32 Grad - Shoots explosive projectiles.
Prototype Shingen: Mark V
Smart Submachinegun
Location: Arroyo, Main Job Gimme Danger, container 667.
Base Weapon: TKI-20 Shingen - fires explosive rounds.
Archangel
Power Revolver
Location: Arroyo, Side Job A Like Supreme, given by Kerry.
Base Weapon: Overture - Reduced recoil and chance to stun targets.
Eastern Badlands Unique Weapons
Plan B
Power Pistol
Location: Eastern Badlands, Dex Body near Side Job Kold Mirage starting location
Base Weapon: Liberty - Apply Bleeding, shot costs a money instead of a bullet.
Widow Maker
Tech Assault Rifle
Location: Eastern Badlands, Main Job Ghost Town, looted from nash
Base Weapon: M-179 Achilles - Fires two bullets per shot, chemical damage and Poison.
Crash
Power Revolver
Location: Eastern Badlands, Side Job Following the River, River on top of water tower.
Base Weapon: Overture
Overwatch
Power Sniper Rifle
Location: Eastern Badlands, Side Job Riders on the Storm, reward for saving Saul.
Base Weapon: SPT32 Grad - Custom silencer and increased reload speed.
Problem Solver
Power Submachinegun
Location: Eastern Badlands, Side Job Riders On the Storm, dropped by enemy.
Base Weapon: M221 Saratoga - Increased ammo clip size and fire rate.
Amnesty
Power Revolver
Location: Eastern Badlands, Main Job We Gotta Live Together (Panam Ending), Cassidy's bottle shooting challenge.
Base Weapon: Overture - Improved handling and firepower.
Stinger
Knife
Location: Eastern Badlands, Side Job I'll Fly Away
Base Weapon: Knife - additional chemical damage and Poison.
The Glen Unique Weapons
La Chingona Dorada
Power Pistol
Location: The Glen, Side Job Heroes, table with offerings.
Base Weapon: Nue - reduced reload time, extra mod slot, can burn and stun.
Tinker Bell
One-Handed Club
Location: The Glen, Side Job The Hunt, Eastern Badlands, Edgewood farm near tree.
Base Weapon: Electric Baton Gamma - Reduced damage, but Stun.
Vista Del Rey Unique Weapons
Skippy
Smart Pistol
Location: Vista Del Rey, Side Job Machine Gun
Base Weapon: TKI-20 Shingen - Scales to your level
Wellsprings Unique Weapons
Yinglong
Smart Submachinegun (have to be crafted)
Location: Wellsprings, boss in Suspected Organized Crime Activity
Base Weapon: G-58 Dian - high electrical damage.
Corpo Plaza Unique Weapons
Pride
Power Pistol
Location: Corpo Plaza, Main Job Knockin' on Heaven's Door.
Base Weapon: Liberty - Increased Crit Chance.
The Caretaker's CyberSpade
Two-Handed Hammer
Location: Corpo Plaza, Main Job Knockin' on Heaven's Door, near conference table.
Base Weapon: Two-Handed Hammer - high damage.